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SUMMARY:UCSC Summer Academy on Artificial Intelligence for High School Students
DESCRIPTION:UCSC’s Summer Academy on Artificial Intelligence is a four-week\, in-person program for talented and motivated high school students who are interested in exploring artificial intelligence (AI) in a university setting. Hosted at the UCSC Silicon Valley Campus\, the program offers an immersive learning experience that combines foundational AI concepts with hands-on\, research-inspired work. Students learn from UCSC professors and active PhD researchers\, gaining advanced problem-solving skills\, research-oriented thinking\, and a deeper understanding of how AI is applied in cutting-edge innovations. \nApplication Deadline: April 24\, 2026
URL:https://live-events-ucsc.pantheonsite.io/event/ucsc-summer-academy-on-artificial-intelligence-for-high-school-students/
LOCATION:3175 Bowers Avenue Santa Clara\, CA 95054\, 3175 Bowers Avenue\, Santa Clara\, CA\, 95054\, United States
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DTSTART;TZID=America/Los_Angeles:20260717T113000
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SUMMARY:Calicchio\, A. (BMEB) - Comparison of long-read sequencing and analysis methods for transcriptome analysis
DESCRIPTION:Alternative splicing\, the process generating different RNA isoforms from a single gene\, is considered one of the main factors driving increased organism complexity in eukaryotes. Variations in isoform and gene expression produce the functional differences that give rise to different cell types and\, in some cases\, result in disease. Long-read RNA sequencing has transformed our ability to characterize isoforms\, since single reads can span full-length transcripts\, but limitations still prevent our identification of all the isoforms in the human transcriptome. Our research proposes to improve both the library preparation and computational analysis steps of the isoform identification process.\nTo do so\, we are updating the isoform identification and quantification tool IG28 (previously called Mandalorion) so that it can analyse both bulk and single-cell long-read sequencing data and. By pairing our analysis with single-cell clustering in Seurat\, we can generate transcriptomes for hundreds of thousands of single cells\, for individual cell types\, and for bulk datasets containing hundreds of millions of reads\, providing a scalable approach to identify isoforms in the largest and most recent datasets.\nFurthermore\, since long reads can carry both the variants defining an allele of origin and the full isoform structure\, we plan to extend IG28 to perform allele-specific transcript usage analysis. We plan to include accurate statistical tests in this module by using beta-binomial and Dirichlet-multinomial models that account for overdispersion\, to provide a tested and integrated pipeline for isoform allelic assignment.\nFinally\, recognizing that isoform detection depends on the quality\, length\, and throughput of the input data\, we are improving library preparation and benchmarking sequencing technologies. We are refining the R2C2 protocol coupled with size selection to overcome the current circularization limit for fragments beyond 6 kb\, and we are generating matched datasets to compare R2C2 to the Kinnex library preparation method\, and ONT against PacBio HiFi sequencing\, to determine which approaches produce the most accurate and longest reads for isoform identification.\nTogether\, these advances will provide a competitive pipeline\, from cDNA preparation to isoform identification and annotation\, enabling accurate isoform annotations that can lead to a deeper understanding of cell differentiation and disease etiology. \nEvent Host: Alessandro Calicchio\, Ph.D. Student\, Biomolecular Engineering & Bioinformatics \nAdvisor: Christopher Vollmers \nZoom: https://ucsc.zoom.us/j/92704819548?pwd=PUqQpq0Soandz8E5DIPCXFdvnFaf00.1 \nPasscode: 760165
URL:https://live-events-ucsc.pantheonsite.io/event/calicchio-a-bmeb-comparison-of-long-read-sequencing-and-analysis-methods-for-transcriptome-analysis/
LOCATION:Biomedical Sciences Building\, 575 McLaughlin Drive
CATEGORIES:Ph.D. Presentations
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DTSTART;TZID=America/Los_Angeles:20260717T120000
DTEND;TZID=America/Los_Angeles:20260717T170000
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SUMMARY:Spring Exhibitions at the Institute of the Arts and Sciences
DESCRIPTION:Visit the IAS\, UCSC’s premier art galleries\, for our spring exhibitions. On view April 10–August 16\, 2026 are three diverse and interdisciplinary shows: Libia Posada: Everything is Going Right\, the first US solo exhibition by the Colombia-based artist and medical doctor; Gina Athena Ulysse: A Redwoods Rasanblaj\, a site-specific and immersive exploration of the Haitian kreyol conception of rasanblaj; and Ronaldo V. Wilson: There Are No Words\, But Melodies\, a mixed-media exhibition emerging at the intersections of Black poetics\, performance\, and visual art. \nThe IAS Galleries are open Wednesday-Sunday\, 12 pm – 5 pm. Admission is free to the public. \nLibia Posada: Everything is Going Right\nLibia Posada’s first solo exhibition in the United States features installations\, sculptures\, and drawings meticulously constructed from surgical instruments\, gauze bandages\, crutches\, used books\, and domestic picture frames. The new and existing works in the exhibition powerfully stitch together the personal\, social\, and political disorders and afflictions that currently trouble the world\, from the wars that resonate across the globe to the violences of aging in US prisons.  \nGina Athena Ulysse: A Redwoods Rasanblaj: Origins & Disentanglements\nThe internationally-lauded work of humanities professor Gina Athena Ulysse is on view as a premier Faculty Spotlight Exhibition. The site-specific installation\, produced in community from things collected\, found\, purchased and donated\, centers on the Haitian concept of rasanblaj\, a form of assembly and collage that transcends the formal use of materials to draw together people\, spirits\, and ideas.  \nRonaldo V. Wilson: There Are No Words\, But Melodies\nCollage is both a material practice and a structural interrogation in the Faculty Spotlight Exhibition artworks by literature professor Ronaldo V. Wilson. In video\, painting\, and installation\, layers and folds conceal and reveal\, delving into the experience\, both bodily and emotive\, of living in times of violence.  \n 
URL:https://live-events-ucsc.pantheonsite.io/event/spring-exhibitions-at-the-institute-of-the-arts-and-sciences/2026-07-17/
LOCATION:Institute of the Arts and Sciences\, 100 Panetta Ave\, Santa Cruz\, United States
CATEGORIES:Exhibits
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