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DTSTART;TZID=America/Los_Angeles:20260603T090000
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UID:10014887-1780477200-1780484400@live-events-ucsc.pantheonsite.io
SUMMARY:Morey\, C. (BMEB) - Innovations in Interdependence: Genomic and Functional Evolution in Invertebrates and Their Intracellular Symbionts
DESCRIPTION:Intracellular symbionts are microorganisms\, such as bacteria\, that live within host cells. These associations are widespread throughout the invertebrate tree of life\, and can perform a diversity of key metabolic\, immune-response\, or other functions that the host is dependent on for survival or reproduction. Intracellular symbioses allow both the host and the symbiont to occupy new ecological niches\, and thus can have profound impacts on their evolution. Recent and rapid growth of available sequencing data provides new opportunities to investigate the genomic alterations underpinning functional and morphological changes during the evolution of these relationships\, and how they reshape both host and symbiont biology. \nHere\, I propose investigating unique mechanisms of genomic innovation across three levels of host-symbiont evolution: symbiont genome evolution\, host-symbiont regulatory co-evolution\, and host genome evolution. In aim 1\, I will investigate how mobile genetic elements drive episodic genome expansion and functional innovation in obligate chemosynthetic symbionts of deep-sea clams\, further challenging the notion that reductive genome evolution is an inevitable or linear fate for host-restricted lineages. In aim 2\, I will explore the potential for symbiont-derived small-RNA molecules to participate in cross-kingdom gene regulation of their hosts across a diversity of host-symbiont systems using publicly available genome and RNA-sequencing data. In aim 3\, I will explore the convergent evolution of gut loss across independently derived marine bivalve lineages that depend nutritionally on chemosynthetic symbionts\, identifying host genomic changes associated with the transition to a symbiotic lifestyle. Together\, these aims leverage the expanding wealth of genomic data to illuminate how host-symbiont relationships reshape the genomes of both partners and generate novel adaptations across evolutionary time. \nEvent Host: Camryn Morey\, Ph.D. Student\, Biomolecular Engineering & Bioinformatics \nAdvisor: Shelbi Russell and Russ Corbett-Detig \nZoom: https://ucsc.zoom.us/j/92296748824?pwd=kabPBvby5xZbAHBbxBX6IIHNka8sLX.1 \nPasscode: 153631
URL:https://live-events-ucsc.pantheonsite.io/event/morey-c-bmeb-innovations-in-interdependence-genomic-and-functional-evolution-in-invertebrates-and-their-intracellular-symbionts/
LOCATION:Biomedical Sciences Building\, 575 McLaughlin Drive
CATEGORIES:Ph.D. Presentations
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DTSTART;TZID=America/Los_Angeles:20260603T130000
DTEND;TZID=America/Los_Angeles:20260603T170000
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UID:10014860-1780491600-1780506000@live-events-ucsc.pantheonsite.io
SUMMARY:22nd Annual Graduate Research Symposium
DESCRIPTION:This event celebrates and highlights the work of UCSC graduate students in all academic divisions. Enrolled graduate students will present either a poster\, talk\, or mixed media presentation. Judges will select and award a top prize for each academic division. This event is free and open to the public. \nLocation : Science Hill\nResearch talks will be scheduled in BioMed 200\, BioMed 300 and PSB 240 from 1:00 – 2:30 PM\nThe poster session will be outside on the Plaza between PSB and the Science & Engineering Library\, 2:30 – 4:00 PM
URL:https://live-events-ucsc.pantheonsite.io/event/22nd-annual-graduate-research-symposium/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Ph.D. Presentations,Seminars
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260603T150000
DTEND;TZID=America/Los_Angeles:20260603T180000
DTSTAMP:20260602T193539Z
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UID:10014898-1780498800-1780509600@live-events-ucsc.pantheonsite.io
SUMMARY:Xu\, D. (BMEB) - Interplay Between CENP-A\, DNA Methylation\, and H3K9me3 in Defining Centromere Identity
DESCRIPTION:Centromeres ensure proper chromosome segregation during cell division\, yet the organization and regulation of centromeric chromatin within satellite DNA arrays remain incompletely understood. Here\, we leverage the complete diploid human genome benchmark (T2T-HG002) to provide a detailed study of centromeric sequence and chromatin architecture on individual haplotypes. Using adaptive-sampling-enriched\, ultra-long-read DiMeLo-seq\, we achieve single-molecule chromatin profiling across all centromeres\, revealing that along single chromatin fibers\, CENP-A\, the histone variant specifying centromere identity\, forms multiple discrete subdomains within hypomethylated centromere dip regions (CDRs) that are flanked by H3K9me3-enriched heterochromatin. Despite underlying sequence variation\, CDRs localize to sequence-homogeneous domains and maintain relatively balanced CENP-A dosage and aggregate length across all chromosomes and between haplotypes. Further\, we show that bidirectional changes to centromeric and pericentromeric DNA methylation are accompanied by changes to centromeric chromatin architecture. In passaged cells with centromeric hypomethylation\, subdomain boundaries are eroded\, and adjacent CENP-A domains tend to merge and expand. Conversely\, in pluripotent stem cells with centromeric hypermethylation\, CDRs are fundamentally reorganized\, such that discrete hypomethylated domains are frequently consolidated into broader contiguous tracts. These methylation-associated CDR restructuring events suggest that DNA methylation acts as a principal regulator of human centromere organization\, with implications for understanding centromere plasticity\, epigenetic inheritance\, and chromosomal instability in development and disease. \nEvent Host: Daniel Xu\, PhD Candidate\, Biomolecular Engineering & Bioinformatics  \nAdvisor: Karen Miga \nZoom: https://ucsc.zoom.us/j/99197563825?pwd=meEWoi4ffdZ0K4Syo09Jr0ZbpPThMk.1
URL:https://live-events-ucsc.pantheonsite.io/event/xu-d-bmeb-interplay-between-cenp-a-dna-methylation-and-h3k9me3-in-defining-centromere-identity/
LOCATION:Engineering 2\, Engineering 2 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Ph.D. Presentations
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