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DTSTART;TZID=America/Los_Angeles:20260820T130000
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DTSTAMP:20260814T163909Z
CREATED:20260814T163815Z
LAST-MODIFIED:20260814T163909Z
UID:10015340-1787230800-1787238000@live-events-ucsc.pantheonsite.io
SUMMARY:Penunuri\, G. (BMEB) - Genomic\, Proteomic\, and Computational Approaches to the Study of Host-Microbe Systems
DESCRIPTION:Host-microbe systems are core to some of biology’s most consequential interactions\, from the pathogens that drive infectious disease to symbionts affecting agricultural pest control and vector-borne disease transmission. Yet unlike the model organisms that have driven most of modern molecular biology\, the microbes at the center of these interactions are rarely genetically tractable: many cannot be cultured outside a host\, resist standard tools for genetic manipulation\, and are annotated largely by homology to distantly related free-living relatives. This dissertation develops genomic\, proteomic\, and computational methods to work around this lack of infrastructure and contribute techniques and tools to the study and further understanding of host-microbe systems. Using Wolbachia cultured in Drosophila melanogaster cell lines\, I demonstrate that chemical mutagenesis can be used to perturb intracellular genomes leaving a detectable mutational signal. I employ a low error rate sequencing technique to record and model the mutational landscape left by the mutagen ethyl methanesulfonate (EMS) demonstrating its use for mutagenesis screens of intracellular bacteria. I next utilize structural proteome datasets to screen host-microbe proteomes for strong candidates of molecular mimicry\, microbe proteins that have coevolved a eukaryotic like domain or structure and suggest use for host manipulation or microbe survival in the host environment. Building off of this screen for novel effectors through structural alignments I develop and test a distributed computing system for performing large scale systematic literature reviews. Altogether these projects represent generalizable approaches to the study of host-microbe systems reaching from classically studied and thoroughly understood to novel and non-model systems. \nEvent Host: Gabriel Penunuri\, Ph.D. Candidate\, Biomolecular Engineering & Bioinformatics  \nAdvisor: Russell Corbett-Detig \nZoom: https://ucsc.zoom.us/j/98216883331?pwd=uqmUSQba2X6GVNBhOhAGRwgCZyjAyj.1 \nPasscode: 730377
URL:https://live-events-ucsc.pantheonsite.io/event/penunuri-g-bmeb-genomic-proteomic-and-computational-approaches-to-the-study-of-host-microbe-systems/
LOCATION:Biomedical Sciences Building\, 575 McLaughlin Drive
CATEGORIES:Ph.D. Presentations
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