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DTSTART;TZID=America/Los_Angeles:20260921T113000
DTEND;TZID=America/Los_Angeles:20260921T123000
DTSTAMP:20260914T191617Z
CREATED:20260914T191617Z
LAST-MODIFIED:20260914T191617Z
UID:10017053-1789990200-1789993800@live-events-ucsc.pantheonsite.io
SUMMARY:Headrick\, C. (BMEB) - The Regulation of mRNA Cleavage in Nonsense-mediated mRNA Decay: From Inside (intra-pathway determinants) Out (extra-pathway regulation)
DESCRIPTION:Nonsense-mediated mRNA decay (NMD) is a translation-coupled quality control pathway that degrades mRNAs that harbor a premature termination codon (PTC) and 5-30% of normal cellular mRNAs. The NMD field sits at a pivotal moment with recent developments that endonucleolytic cleavage is the primary mechanism of mRNA decay conserved across metazoans. Discovery of a conserved NMD cleavage mechanism sets the stage for a dissection of mRNA cleavage determinants and regulators. \nTo better understand how mRNA cleavage during NMD is regulated\, I will use degradome-seq based approaches via 5’RACE-seq (Rapid Amplification of 5’ cDNA Ends) to isolate the cleavage products of the NMD pathway. I will first focus my analysis on core NMD factors and helicase UPF1\, the binding site of NMD decay effectors\, to examine how UPF1 enzymatic activity affects mRNA cleavage transcriptome-wide (Aim 1). In parallel\, to assess extra-pathway regulation of mRNA cleavage during NMD\, I will identify endogenous negative regulators of mRNA cleavage (Aim 2). Contemporary models of NMD are deprived of the functional impact of cellular NMD inhibitors. I will access this novel functional space with an innovative application of CRISPR screening and quantitative\, high-throughput NGS\, known as ReLiC (RNA-linked CRISPR) paired with degradome analysis. \n  \nEvent Host: Camille Headrick\, Ph.D. Student\, Biomolecular Engineering & Bioinformatics  \nAdvisor: Joshua Arribere \n 
URL:https://live-events-ucsc.pantheonsite.io/event/headrick-c-bmeb-the-regulation-of-mrna-cleavage-in-nonsense-mediated-mrna-decay-from-inside-intra-pathway-determinants-out-extra-pathway-regulation/
LOCATION:Biomedical Sciences Building\, 575 McLaughlin Drive
CATEGORIES:Ph.D. Presentations
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260925T103000
DTEND;TZID=America/Los_Angeles:20260925T113000
DTSTAMP:20260921T180343Z
CREATED:20260916T211025Z
LAST-MODIFIED:20260921T180343Z
UID:10017076-1790332200-1790335800@live-events-ucsc.pantheonsite.io
SUMMARY:ECE Special Seminar: "Autonomous Electric Vehicles – Data Centers on the Wheel"
DESCRIPTION:Presented by: Kaushik Rajashekara\, Hugh Roy and Lillie Cranz Cullen Distinguished University Professor @ University of Houston \nDescription: “Autonomous electric vehicles (AEVs) are at the forefront of modern transportation\, merging automation with sustainability to enhance efficiency and safety while reducing environmental impact. However\, these vehicles face significant challenges in balancing the energy demands of autonomous compute systems with propulsion efficiency and vehicle range. The sensors\, LiDAR\, cameras\, and AI inference hardware required for Level 4 autonomy draw significant continuous compute power — entirely separate from propulsion. This power is comparable to a server-class GPU — making each AEV\, in effect\, a data center on wheels. This presentation explores that compute energy load\, examines how it scales across projected global AV fleets\, and compares it with the energy consumption and CO₂ emissions of global data centers. The presentation concludes with current challenges and future trends in the key enabling technologies — next-generation batteries\, wide-bandgap power electronics\, high-efficiency electric machines\, and can scale without proportionally scaling its energy and emissions footprint.” \nBio: Kaushik Rajashekara (Fellow\, IEEE) received the Ph.D. degree in electrical engineering from the Indian Institute of Science\, Bangalore\, India. He held various lead technical and managerial positions at Delphi/General Motors (1989–2006)\, serving as Technical Fellow and Chief Scientist for propulsion and power electronics systems for electric\, hybrid\, and fuel cell vehicles.From 2006 to 2012\, he was Chief Technologist and Rolls-Royce Fellow for electric systems for electric and hybrid electric aircraft at Rolls-RoyceCorporation. From 2012 to 2016\, he was a Distinguished Professor at the University of Texas at Dallas. He is currently the Hugh Roy and Lillie Cranz Cullen Distinguished University Professor at the University of Houston. \nHe has authored over 300 papers and one book\, holds 37 U.S. and 15 foreign patents\, and has delivered over 250 invited presentations worldwide. His honors include the Global Energy Prize\, the IEEE Medal for Environmental and Safety Technologies\, and the IEEE Richard Harold Kaufmann Award. He is a member of the U.S. National Academy of Engineering\, a Fellow of the National Academy of Inventors\, aFellow of the European Academy of Sciences\, and an International Fellow of the Indian\, Chinese\, Canadian\, and Japanese Academies of Engineering. His research interests include power conversion\, transportation electrification\, renewable energy\, offshore systems\, and microgrid systems. \n  \nHosted by: Professor Leila Parsa\, Electrical & Computer Engineering Department \nWhen: Friday\, September 25\, 2026 @ 10:30 AM PST \nLocation: E2-506 \n  \n 
URL:https://live-events-ucsc.pantheonsite.io/event/ece-special-seminar-autonomous-electric-vehicles-data-centers-on-the-wheel/
LOCATION:Engineering 2\, Engineering 2 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260925T130000
DTEND;TZID=America/Los_Angeles:20260925T150000
DTSTAMP:20260911T151906Z
CREATED:20260911T151906Z
LAST-MODIFIED:20260911T151906Z
UID:10017048-1790341200-1790348400@live-events-ucsc.pantheonsite.io
SUMMARY:Mastoras\, M. (BMEB) - Polishing genome assemblies and leveraging their improved quality to study centromere variation
DESCRIPTION:A complete and accurate genome reconstruction serves as the foundation for studying an organism’s biology and the mechanisms underlying disease. It is particularly critical for reference genomes\, which provide a universal coordinate system for downstream genomic analysis. Errors or missing sequences in a reference genome create bias in all of the studies built on top of them. The Human Pangenome Reference Consortium (HPRC) seeks to address this bias by transitioning the field to a pangenome reference\, a graph based collection of many genome assemblies\, providing a better representation of variation in the human population. Removing errors in the HPRC assemblies is critical to ensure the pangenome serves as a robust standard for genomic variant discovery. In the first part of my thesis\, I improve the base level accuracy of the HPRC release 2 assemblies (HPRC2) with a machine learning model for assembly polishing called DeepPolisher. Next\, I make additional contributions to reference-based genomic analysis by polishing reference genomes of other model organisms\, and helping to develop a new method for de-novo assembly and variant calling from a single-flow cell nanopore sequencing protocol. Finally\, I take advantage of the highly accurate\, near complete assemblies from HPRC2 that I improved with DeepPolisher to study a region only recently made accessible to genomics analysis: the human centromere. I apply the tool Centrolign\, the first ever multiple-sequence-aligner for centromeres to the HPRC2 assemblies\, establishing precise estimates of mutation rates and spatial variation patterns across centromeric arrays. \nEvent Host: Mira Mastoras\, Ph.D. Candidate\, Biomolecular Engineering & Bioinformatics \nAdvisor: Benedict Paten \nZoom: https://ucsc.zoom.us/j/98960011053?pwd=mFKCwtSIhvT5FvEURbE85lRbbMvzuo.1 \nPasscode: 118488
URL:https://live-events-ucsc.pantheonsite.io/event/mastoras-m-bmeb-polishing-genome-assemblies-and-leveraging-their-improved-quality-to-study-centromere-variation/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Ph.D. Presentations
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260925T150000
DTEND;TZID=America/Los_Angeles:20260925T160000
DTSTAMP:20260922T172213Z
CREATED:20260922T172213Z
LAST-MODIFIED:20260922T172213Z
UID:10017558-1790348400-1790352000@live-events-ucsc.pantheonsite.io
SUMMARY:Malekos\, E. (BMEB) - CRISPR screens of noncanonical ORFs uncover retroviral-derived immune regulators
DESCRIPTION:Ribosome profiling has revealed thousands of noncanonical translation events across mammalian genomes\, yet functional characterization has overwhelmingly focused on proliferative fitness in cancer cell lines. Here\, we present a comprehensive survey of noncanonical translation in the mouse immune system and its functional consequences in macrophages. By performing a unified Ribo-seq meta-analysis across 20 public mouse leukocyte datasets – spanning macrophages\, dendritic cells\, neutrophils\, B cells\, and T cells – we define a compendium of 22\,276 noncanonical coding sequences (CDSs)\, including upstream ORFs (uORFs)\, downstream ORFs\, and ORFs on noncoding RNAs and pseudogenes (ncORFs). Proteogenomic integration with reanalyzed mass spectrometry data prioritizes a high-confidence subset with detectable protein products\, including pseudogene-encoded and lncRNA-encoded zinc finger proteins. To move beyond cataloging\, we carried out two orthogonal CRISPR screens in immortalized bone marrow-derived macrophages: a fitness screen identifying noncanonical CDSs required for macrophage viability\, and a TLR1/TLR2-NFκB reporter screen uncovering CDSs that modulate innate immune signaling. These screens nominate uORFs\, several conserved between mouse and human\, that exert phenotypic effects on par with their cognate coding sequences. We unexpectedly discovered a family of endogenous retroviral envelope-derived proteins translated in adult myeloid cells. Among these\, SYNIR is a full-length syncytin-like membrane glycoprotein that positively regulates NFκB-responsive transcription\, while SEMR is a secreted protein with structural homology to the feline leukemia virus accessory protein FeLIX that drives broad transcriptional remodeling of macrophage gene programs upon knockout. Updated single-cell RNA-seq annotations and an interactive UCSC Genome Browser session integrating Ribo-seq\, proteomics\, and CRISPR screen data are provided as community resources. Together\, these findings expand the functional landscape of noncanonical translation in immunity and establish endogenous retroviral proteins as previously unrecognized regulators of macrophage biology. \nEvent Host: Eric Malekos\, Ph.D. Candidate\, Biomolecular Engineering & Bioinformatics  \nAdvisor: Susan Carpenter
URL:https://live-events-ucsc.pantheonsite.io/event/malekos-e-bmeb-crispr-screens-of-noncanonical-orfs-uncover-retroviral-derived-immune-regulators/
LOCATION:Biomedical Sciences\, Biomedical Sciences Building Red Hill Road\, Santa Cruz\, CA\, 95064
CATEGORIES:Ph.D. Presentations
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260927T100000
DTEND;TZID=America/Los_Angeles:20260927T120000
DTSTAMP:20260910T220533Z
CREATED:20260910T220533Z
LAST-MODIFIED:20260910T220533Z
UID:10016654-1790503200-1790510400@live-events-ucsc.pantheonsite.io
SUMMARY:Earth Friendly Gardening: Protecting Wildlife & the Environment
DESCRIPTION:Join the UC Master Gardeners of Monterey\, San Benito & Santa Cruz Counties for this hands-on summer workshop at the UCSC Arboretum!\nClasses are free with paid admission\, but registration is required to attend. You are welcome to take one\, two\, or all four classes which occur on the last Sunday of the month\, June through September.\nYour garden can do more than look beautiful – it can help protect the environment and support local wildlife.\nDiscover simple\, practical ways to create a healthier\, more sustainable landscape by providing food\, water\, and shelter for pollinators\, birds\, and other beneficial creatures. Learn how to reduce pesticide and fertilizer use\, conserve water\, and work with nature to grow a thriving garden that’s easier to maintain and better for the world around you.\nClasses are free for UCSC Students or with an Arboretum membership which includes free admission to the gardens as well as a whole host of great benefits. Consider becoming a member today by visiting our website: arboretum.ucsc.edu
URL:https://live-events-ucsc.pantheonsite.io/event/earth-friendly-gardening-protecting-wildlife-the-environment/
CATEGORIES:Lectures & Presentations,Workshop
ATTACH;FMTTYPE=image/webp:https://live-events-ucsc.pantheonsite.io/wp-content/uploads/2026/09/UC-Mater-Gardener-Protecting-Wildlife.webp
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260927T130000
DTEND;TZID=America/Los_Angeles:20270627T150000
DTSTAMP:20260910T220505Z
CREATED:20260910T220505Z
LAST-MODIFIED:20260910T220505Z
UID:10016362-1790514000-1814108400@live-events-ucsc.pantheonsite.io
SUMMARY:Santa Cruz Pickwick Club presents: Christie Mysteries
DESCRIPTION:Over the coming year\, Dickens Universe readers and Pickwick Club members will meet for discussions focused on these novels and their lasting influence on the mystery genre. This year’s reading series brings together four landmark works of crime fiction: The Mystery of Edwin Drood by Charles Dickens (Penguin Classics\, 2002)\, The Murder of Roger Ackroyd by Agatha Christie (William Morrow\, 2021)\, The Murder at the Vicarage by Agatha Christie (William Morrow\, 2025)\, and The Pale Horse by Agatha Christie (William Morrow\, 2011). Join Dickens enthusiasts and Pickwick Club members on Zoom for a series of discussions about these beloved books. \nRegister via Zoom \nReading Schedule:  \n\nSept 27: The Murder of Roger Ackroyd\nOct 25: The Pale Horse\nNov 22: The Murder at the Vicarage\nDec 27: The Mystery of Edwin Drood\nJan 24: The Mystery of Edwin Drood\nFeb 28: The Mystery of Edwin Drood\nMar 28: The Mystery of Edwin Drood\nApr 25: TBD\nMay 23: TBD\nJun 27: TBD\n\nRecommended Edition: We recommend the Penguin Classics edition of the novels for its appendices and notes\, but other versions are fine. First-time readers should avoid the Introduction if they don’t want spoilers. Download the novels to read at Gutenburg.org or listen at LibriVox.org. \nThe Santa Cruz Pickwick (Book) Club\, a branch of the Dickens Fellowship\, is a community of local bookworms\, students\, and teachers who meet monthly to discuss a nineteenth-century novel. The Santa Cruz Public Libraries provide support for the reading group.
URL:https://live-events-ucsc.pantheonsite.io/event/santa-cruz-pickwick-club-presents-christie-mysteries/2026-09-27/
CATEGORIES:Lectures & Presentations
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