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DTSTART;TZID=America/Los_Angeles:20260416T110000
DTEND;TZID=America/Los_Angeles:20260416T130000
DTSTAMP:20260408T202602Z
CREATED:20260408T202602Z
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SUMMARY:Mirchandani\, C. (BMEB) - Population and Evolutionary Genomics Across Ecological Scales
DESCRIPTION:Sequencing technologies have transformed population and evolutionary genetics\, making it possible to ask questions at scales that were intractable a decade ago. Realizing that potential depends on tailored computational approaches\, and on the tools and infrastructure those approaches are built on. My dissertation works across this spectrum. Using an in vitro Drosophila cell culture system\, I show that mixed Wolbachia infections resolve rapidly and deterministically\, with one strain competitively excluding the other across host species and starting frequencies\, offering an explanation for why mixed infections are rarely observed in nature. In a deep-sea clam and its obligate bacterial symbiont\, I use two ultra-accurate sequencing methods and demographic modeling to directly estimate the effective transmission bottleneck between host generations\, finding it to be roughly eight symbionts\, orders of magnitude below prior cell-count estimates. I also present two tools for population genomics at scale: snpArcher\, a reproducible variant calling workflow developed for the California Conservation Genomics Project and now used across hundreds of species and tens of thousands of samples; and clam\, a Rust-based tool that efficiently estimates population genetic statistics by leveraging callable loci\, producing results identical to existing all-sites approaches at a fraction of the computational cost. Together\, these projects demonstrate how tailored computational approaches can unlock biological insight across diverse systems and scales. \nEvent Host: Cade Mirchandani\, Ph.D. Candidate\, Biomolecular Engineering & Bioinformatics \nAdvisors: Russ Corbett-Detig & Shelbi Russell \nZoom- https://ucsc.zoom.us/j/98034081971?pwd=L5RoKoNEFxyapNhSRoXC8os2K2YZwv.1
URL:https://live-events-ucsc.pantheonsite.io/event/mirchandani-c-bmeb-population-and-evolutionary-genomics-across-ecological-scales/
LOCATION:Engineering 2\, Engineering 2 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Ph.D. Presentations
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260415T173000
DTEND;TZID=America/Los_Angeles:20260415T203000
DTSTAMP:20260402T171331Z
CREATED:20260325T220453Z
LAST-MODIFIED:20260402T171331Z
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SUMMARY:Kraw Lecture: At the Forefront of AI: Innovation and Discovery
DESCRIPTION:Artificial intelligence is transforming how we understand and solve the world’s most complex challenges—while at the same time causing new challenges and concerns. We invite you to join us for a special UC Santa Cruz Kraw Lecture showcasing the faculty whose groundbreaking research in artificial intelligence is transforming science\, technology\, and society. From advances in autonomous systems and natural language processing to the development of sustainable and responsible AI\, this conversation will highlight the innovative work taking place across disciplines and the real-world impact it is poised to have. \nModerated by special guest Ahmad Thomas\, CEO of the Silicon Valley Leadership Group (SVLG)\, this dynamic discussion will bring together leading researchers to explore how these technologies are shaping the future—accelerating discovery\, addressing complex global challenges\, and opening new frontiers for collaboration. Gain insight into the ideas\, discoveries\, and collaborations shaping the next generation of artificial intelligence research and hear from the leaders advancing this work.\n \n\n\nIn-Person Reception: 5:30 p.m.\nLecture: 6:15 p.m.\n\nRegister Now
URL:https://live-events-ucsc.pantheonsite.io/event/kraw-lecture-at-the-forefront-of-ai-innovation-and-discovery/
LOCATION:The Quad Conference Center\, 2400 Sand Hill Rd\, Menlo Park\, CA\, 94025\, United States
CATEGORIES:Lectures & Presentations
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260413T132000
DTEND;TZID=America/Los_Angeles:20260413T142500
DTSTAMP:20260409T223335Z
CREATED:20260409T223335Z
LAST-MODIFIED:20260409T223335Z
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SUMMARY:BME 80G Seminar: Speaker Dr. Mohammed Mostajo-Radji - How Close Are We to Consciousness in a Dish?
DESCRIPTION:Presenter: Dr. Mohammed Mostajo-Radji\, Associate Research Scientist\, Genomics Institute UCSC \nDescription: We can now grow small pieces of human brain tissue in the lab\, known as brain organoids. These models show many features of early brain development\, including different types of neurons and coordinated electrical activity. This progress raises a fascinating question: how close are we to consciousness in a dish? In this talk\, I will explain what brain organoids are\, what we mean by consciousness\, and why answering this question is more complex than it may seem. I will end by introducing the idea of neurorights\, and why thinking about the rights and protections of minds matters as brain science and technology continue to advance. \nBio: Dr. Mohammed Mostajo-Radji is an Associate Research Scientist at the Genomics Institute UCSC. He is part of the Braingeneers group\, a multidisciplinary collective of geneticists\, neuroscientists\, and engineers focused on the human brain’s specification and function. His research explores neuronal specification and fate plasticity in the cerebral cortex using brain organoid models. Additionally\, he leads the Live Cell Biotechnology Discovery Lab\, which develops cloud-based experimental science education technologies. Dr. Mostajo-Radji earned his PhD in Molecular and Cellular Biology from Harvard University and completed postdoctoral training at UCSF. He also co-leads the Data Coordination Center for the SSPsyGene Consortium\, an NIH initiative to characterize genetic mutations associated with neuropsychiatric disorders.  \nHosted by: Professor Karen Miga\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-80g-seminar-speaker-dr-mohammed-mostajo-radji-how-close-are-we-to-consciousness-in-a-dish/
LOCATION:Jack Baskin Auditorium\, 191 Baskin Cir\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260410T132000
DTEND;TZID=America/Los_Angeles:20260410T142500
DTSTAMP:20260410T190015Z
CREATED:20260407T233816Z
LAST-MODIFIED:20260410T190015Z
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SUMMARY:BME 80G Seminar: Sara Ackerman - Doing Ethics From The Inside: Collaboration\, Critique\, and Contradiction in Team Science
DESCRIPTION:Presenter: Sara Ackerman\, Medical Anthropologist and Professor of Social and Behavioral Sciences\, University of California\, San Francisco \nDescription: Team science has been widely promoted as a collaborative\, cross-disciplinary approach to addressing key scientific questions\, yet power differences and epistemic hierarchies persist. This talk explores "embedded ethics"—a model in which social scientists and ethicists work directly with scientific research teams. Drawing on findings from an empirical ethics project embedded in a multi-year clinical genomics study\, I demonstrate how qualitative methods and participatory design can shift the researcher-participant dynamic toward greater reciprocity and attention to enrolled families’ experiences. At the same time\, ethicists and social scientists can find themselves in an uncomfortable and even paradoxical position\, expected to facilitate project goals—such as recruitment of historically underrepresented groups—while simultaneously critically assessing the very categories of difference and measures being used. In the future\, team science collaborations can result in more just and broadly beneficial science if social science\, humanities and community partners are able to meaningfully contribute to the research agenda itself. \nBio: Sara Ackerman\, PhD\, MPH\, is a medical anthropologist and Professor of Social and Behavioral Sciences at the University of California\, San Francisco. Her research draws on ethnographic methods and public engagement to examine how genomics\, artificial intelligence and other emerging medical technologies affect the lives of patients and caregivers and shape conceptions of health\, illness and the public good. Sara teaches courses on community-engaged research\, qualitative methods\, and research ethics at UCSF. As Director of the Bioethics and Regulatory Support Program for UCSF’s Clinical and Translational Science Institute\, she is working to increase patient and public participation in decisions about the use of AI in clinical care and the sharing of patients’ clinical data for research. \nHosted by: Professor Karen Miga\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-80g-seminar-sara-ackerman-doing-ethics-from-the-inside-collaboration-critique-and-contradiction-in-team-science/
LOCATION:Jack Baskin Auditorium\, 191 Baskin Cir\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260407T114000
DTEND;TZID=America/Los_Angeles:20260407T131500
DTSTAMP:20260306T222514Z
CREATED:20260306T222258Z
LAST-MODIFIED:20260306T222514Z
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SUMMARY:Next Wave of Faculty in Genomics Symposium
DESCRIPTION:The BME Department and Genomics Institute are once again hosting our annual Next Wave of Faculty in Genomics Symposium\, which will be held on April 7th from 11:40–1:15 in E2 180. Please join us to hear cutting-edge genomics talks from outstanding postdocs from around the country! \nA burrito reception catered by Alebrije’s will follow immediately after the talks. Registration is free\, but required\, so please RSVP HERE!  \nThis year’s speakers include:  \n\nDr. Yutong Wang\, UC San Francisco\nTalk title: “A genome-wide CRISPR activation screen of surface protein expression in primary human CD4 T cells”\nDr. Ian Traniello\, Princeton\nTalk title: “The Making of a Queen: Neurogenomic Building Blocks of Social Dominance in Bee Societies”\nDr. Alex Cope\, Vanderbilt University\nTalk title: “Unlocking the rules of proteome evolution by integrating evolutionary theory\, mechanistic models\, and functional genomics”\nDr. Conner Langeberg\, UC Berkeley\nTalk title: “Interpreting RNA Foundation Models to Reveal Structure\, Function\, and Biological Organization”
URL:https://live-events-ucsc.pantheonsite.io/event/next-wave-of-faculty-in-genomics-symposium/
LOCATION:Jack Baskin Engineering\, Baskin Engineering 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260403T132000
DTEND;TZID=America/Los_Angeles:20260403T142500
DTSTAMP:20260401T005118Z
CREATED:20260401T005024Z
LAST-MODIFIED:20260401T005118Z
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SUMMARY:BME 80G Seminar: To Infinity and Beyond? Ethical\, legal\, and social issues of human research in space”
DESCRIPTION:Presenter: Vaso Rahimzadeh\, Assistant Professor\, Baylor College of Medicine \nDescription: As humans venture farther into outer space\, new scientific discovery awaits including in genomics; but so do new ethical dilemmas.  Who bears the risks (and rewards) of space exploration and how should humanity ethically expand beyond our planet? This session will have students think critically about the ethical\, legal\, and social issues of human genomic research in space and offer frameworks for analyzing them. Students will learn about the contemporary challenges and opportunities of genomic research for the upcoming lunar missions\, and in anticipation of future Mars exploration. \nBio: I am Assistant Professor at the Center for Medical Ethics and Health Policy at Baylor College of Medicine. In my National Institutes of Health-funded research\, I investigate the ethical\, legal\, and social issues of health data sharing on earth and in space. I aim to inform policy and practice in ways that maximize the scientific value of data while respecting the rights and interests of individuals and communities. I director the METEORS program (Mission to Enhance eThics Education\, Outreach\, and Research in Space) and serve on the Bioethics Advisory Panel for the National Aeronautics and Space Administration (NASA). I am a proud UC alum\, earning my BS in Microbial Biology from UC Berkeley in 2012\, and hold a PhD from McGill University with a specialization in biomedical ethics. You can read more about my background and read my work here. \nHosted by: Professor Karen Miga\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-80g-seminar-to-infinity-and-beyond-ethical-legal-and-social-issues-of-human-research-in-space/
LOCATION:Jack Baskin Auditorium\, 191 Baskin Cir\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260402T114000
DTEND;TZID=America/Los_Angeles:20260402T131500
DTSTAMP:20260401T004313Z
CREATED:20260401T004313Z
LAST-MODIFIED:20260401T004313Z
UID:10011828-1775130000-1775135700@live-events-ucsc.pantheonsite.io
SUMMARY:BME 280B Seminar: Small changes\, Big consequences: Modulators of Alphavirus Assembly
DESCRIPTION:Presenter: Dr. Suchetana (Tuli) Mukhopadhyay\, Professor\, Indiana University \nDescription: N/A \nBio: Suchetana “Tuli” Mukhopadhyay\, Ph.D.\, is a professor in the Department of Biology at Indiana University\, Bloomington. She received her B.A. in chemistry from DePauw University and her Ph.D. in chemistry from the University of Illinois at Chicago. Following her doctoral studies\, Mukhopadhyay conducted postdoctoral research at the University of Texas Southwestern Medical Center\, focusing on G-protein mediated signaling. She continued her postdoctoral work at Purdue University in structural virology\, where she developed a strong interest in arboviruses. Mukhopadhyay joined Indiana University in 2005\, where she established her research program on the assembly and spread of alphaviruses. \nHosted by: Professor Rebecca Dubois\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-small-changes-big-consequences-modulators-of-alphavirus-assembly/
LOCATION:Biomedical Sciences Building\, 575 McLaughlin Drive
CATEGORIES:Lectures & Presentations,Seminars
ATTACH;FMTTYPE=image/jpeg:https://live-events-ucsc.pantheonsite.io/wp-content/uploads/2026/03/mukhopadhyay-tuli-mar28-2017.jpg
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X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Biomedical Sciences Building 575 McLaughlin Drive;X-APPLE-RADIUS=500;X-TITLE=575 McLaughlin Drive:geo:-64.7891251,46.1226939
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260312T114000
DTEND;TZID=America/Los_Angeles:20260312T131500
DTSTAMP:20260303T000204Z
CREATED:20260303T000204Z
LAST-MODIFIED:20260303T000204Z
UID:10009382-1773315600-1773321300@live-events-ucsc.pantheonsite.io
SUMMARY:BME 280B Seminar: Modulating Insulin Receptor Through New Ligands
DESCRIPTION:Presenter: Danny Chou\, Associate Professor of Pediatrics\, Stanford University \nDescription: Since its discovery in 1921\, insulin has been at the forefront of scientific breakthroughs. From its amino acid sequencing to the revelation of its three‐dimensional structure\, the progress in insulin research has spurred significant therapeutic breakthroughs. In recent years\, protein engineering has introduced innovative chemical and enzymatic methods for insulin modification\, fostering the development of therapeutics with tailored pharmacological profiles. In this seminar\, I will highlight the use of new ligands to modulate insulin receptors and discuss how they continue to shape the future trajectory of insulin research. \nBio: Danny Chou is an Associate Professor of Pediatrics and by courtesy\, of Chemical & Systems Biology at Stanford University. He is an affinity group leader at Stanford Diabetes Research Center. His research interests lie in the intersection of peptide therapeutics and metabolic diseases. He started his independent career as an assistant professor of biochemistry at University of Utah in 2014. He moved his lab to Stanford University in 2020 and continued their pursuit of using peptide and protein chemistry to develop therapeutics to address unmet needs.  \nHosted by: Professor Andy Yeh\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-modulating-insulin-receptor-through-new-ligands/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260305T114000
DTEND;TZID=America/Los_Angeles:20260305T131500
DTSTAMP:20260227T202045Z
CREATED:20260223T183015Z
LAST-MODIFIED:20260227T202045Z
UID:10009267-1772710800-1772716500@live-events-ucsc.pantheonsite.io
SUMMARY:BME 280B Seminar: Artificial intelligence systems to advance engineered T cell immunotherapy designs
DESCRIPTION:Presenter: Zinaida Good\, Assistant Professor of Medicine in the Division of Immunology and Rheumatology and the Division of Computational Medicine\, Stanford University \nDescription: T cell immunotherapies have reshaped the treatment landscape for hematologic malignancies and are rapidly extending to solid tumors\, autoimmune diseases\, and transplant tolerance. Yet durable benefit remains inconsistent\, and toxicities remain clinically significant. The current discovery proceeds one edit at a time\, and existing preclinical models do not represent patient biology\, which often results in failure upon clinical translation. Overcoming these challenges to improve patient outcomes and reduce toxicities requires a systems-level understanding of the multiscale factors governing T cell function and toxicity in patients. Artificial intelligence (AI) approaches offer an exciting opportunity to tackle this problem by learning unified representations from diverse data types spanning molecular\, cellular\, and clinical modalities. I will provide an overview on our team’s approaches building AI systems that harness primary patient datasets to directly inform advanced T cell designs optimized for clinical outcomes\, with validation in preclinical models. \nBio: Zinaida Good\, Ph.D.\, is an Assistant Professor of Medicine in the Division of Immunology and Rheumatology and the Division of Computational Medicine at Stanford University. She also serves as the Director of the Stanford Center for Cancer Cell Therapy Data Hub. The goal of her research program is to understand and enhance engineered T cell immunotherapies for cancer and immune-mediated diseases through innovative computational approaches and systems immunology. Her lab leverages innovation in machine learning and clinical multiomic datasets to build artificial intelligence systems for advanced T cell therapy design. Dr. Good earned her Ph.D. in Computational & Systems Immunology from Stanford University. Her work includes 4 first-author papers (Nature Medicine 2018 & 2022\, Nature Biotechnology 2019\, Trends in Immunology 2019)\, 18+ co-authored papers (including Nature 2019\, 2022\, 2024\, Science 2021\, Nature Methods 2016\, 2022\, and NEJM 2024)\, and an initial senior author papers (ICML 2025\, NeurIPS 2025\, Frontiers in Immunology 2025). Her research is supported by the NIH/NCI Pathway to Independence Award\, NIH/OD Multimodal AI Initiative Award\, NIH/NCI Program Project Grant\, and the Weill Cancer Hub West. Dr. Good has been named an Arthur & Sandra Irving Cancer Immunology Fellow in 2022\, Parker Bridge Fellow in 2023\, and an AACR-Woman in Cancer Research Scholar in 2024. \nHosted by: Professor Vanessa Jonsson\, BMEbe Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-artificial-intelligence-systems-to-advance-engineered-t-cell-immunotherapy-designs/
LOCATION:Biomedical Sciences\, Biomedical Sciences Building Red Hill Road\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260226T120000
DTEND;TZID=America/Los_Angeles:20260226T140000
DTSTAMP:20260223T200828Z
CREATED:20260129T143555Z
LAST-MODIFIED:20260223T200828Z
UID:10009134-1772107200-1772114400@live-events-ucsc.pantheonsite.io
SUMMARY:BE Club Bash - Engineers Week
DESCRIPTION:Discover innovation at the Baskin Engineering Club Bash\, an event celebrating National Engineers Week! \nMark your calendars for Thursday\, February 26\, 12–2 PM in the BE Courtyard! The BE Club Bash brings together student organizations across all engineering disciplines to showcase their projects\, demos\, and interactive activities. \nStop by to: \n\nExplore hands-on booths and demonstrations from student organizations\nLearn about engineering opportunities on campus and how to get involved\nChat with student leaders and hear about their experiences\nEnter our 3D printer raffle (must be present to win!)\nGrab snacks and BE swag while you explore\n\nThis is a great way to connect with the engineering community\, discover new ideas\, and have fun. We hope to see you there! RSVP here.
URL:https://live-events-ucsc.pantheonsite.io/event/be-club-bash-engineers-week/
LOCATION:Jack Baskin Engineering\, Baskin Engineering 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Social Gathering,Undergraduate
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260226T114000
DTEND;TZID=America/Los_Angeles:20260226T131500
DTSTAMP:20260212T231636Z
CREATED:20260212T231636Z
LAST-MODIFIED:20260212T231636Z
UID:10009217-1772106000-1772111700@live-events-ucsc.pantheonsite.io
SUMMARY:BME 280B Seminar: The evolution of structural variation across vertebrate genomes
DESCRIPTION:Presenter: Peter Sudmant\, Assistant Professor of Integrative Biology\, University of California\, Berkeley \nDescription: Structural variants (SVs) contribute substantially to genetic variation and play vital roles in adaptation and disease. However\, SVs are poorly captured by short read sequencing and thus are understudied\, particularly in non-model organisms. Here\, taking advantage of recently generated haplotype-resolved genome assemblies from >600 vertebrate species\, we present the most comprehensive survey of the diversity of SVs and single nucleotide variants (SNVs) across the vertebrate tree of life to date. \nBio: Peter Sudmant is an Assistant Professor of Integrative Biology at the University of California Berkeley. Prior to joining UC Berkeley\, Dr Sudmant completed his PhD at the University of Washington in the Lab of Dr Evan Eichler as HHMI International Fellow. Dr Sudmant went on to complete a postdoc with Christopher Burge at MIT as a Genentech fellow of the Life Sciences Research Foundation. Dr Sudmant is a recipient of the American Foundation for Aging Research Junior Faculty Award and a Hellman Fellow. \nHosted by: Professor Russ Corbett-Detig\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-the-evolution-of-structural-variation-across-vertebrate-genomes/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260225T173000
DTEND;TZID=America/Los_Angeles:20260225T190000
DTSTAMP:20260209T232119Z
CREATED:20260130T054047Z
LAST-MODIFIED:20260209T232119Z
UID:10009139-1772040600-1772046000@live-events-ucsc.pantheonsite.io
SUMMARY:Exploring Research Pathways at Baskin Engineering
DESCRIPTION:Curious how being part of a research lab can supercharge your experience as a Baskin Engineer?   \nJoin us for this informative event to learn about opportunities to solve open-ended problems\, build deeper technical skills\, and learn how to think like an engineer. \nWe’ll kick things off with a quick overview of the kinds of research opportunities available to undergrads and how to get started\, then you’ll hear directly from students who’ve worked in research labs as undergraduates. They’ll share what they actually did day-to-day\, the skills they built (technical and professional)\, and how research shaped their confidence\, career goals\, and next steps. We’ll then have pizza and networking to end the evening. \nWhether you’re aiming for industry\, graduate school\, or just want hands-on experience that goes beyond coursework\, this panel will help you understand how undergraduate research can set you apart—academically\, professionally\, and personally! \n\nRegister via Handshake. \nYOU BELONG HERE\nPrograms and services are open to all\, consistent with state and federal law\, as well as the University of California’s nondiscrimination policies. Every initiative—whether a student service\, faculty program\, or community event—is designed to be accessible\, inclusive\, and respectful of all identities. To learn more\, please visit UC Nondiscrimination Statement or Nondiscrimination Policy for UC Publications.
URL:https://live-events-ucsc.pantheonsite.io/event/exploring-research-pathways-at-baskin-engineering/
LOCATION:Engineering 2\, Engineering 2 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260224T103000
DTEND;TZID=America/Los_Angeles:20260224T113000
DTSTAMP:20260209T232106Z
CREATED:20260129T145348Z
LAST-MODIFIED:20260209T232106Z
UID:10009135-1771929000-1771932600@live-events-ucsc.pantheonsite.io
SUMMARY:Transform Your Future Pop-Up (Cookies Included!)
DESCRIPTION:Join Baskin Engineering to celebrate National Engineers Week with a sweet stop at the Transform Your Future Pop-Up (Cookies Included!) 🍪☕ \nThis year’s Engineers Week theme\, Transform Your Future\, is a powerful reminder that engineering doesn’t just shape our world—it shapes our opportunities\, our communities\, and the futures we can imagine for ourselves. \nSwing by the BE Courtyard to grab cookies\, coffee\, and BE swag (first come\, first served!) and take a moment to celebrate how you are transforming your future. \n📅 Date: Tuesday\, February 24⏰ Time: 10:30 a.m.📍 Location: BE Courtyard \nWe hope to see you there!
URL:https://live-events-ucsc.pantheonsite.io/event/transform-your-future-pop-up-cookies-included/
LOCATION:Jack Baskin Engineering\, Baskin Engineering 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Social Gathering,Undergraduate
ATTACH;FMTTYPE=image/jpeg:https://live-events-ucsc.pantheonsite.io/wp-content/uploads/2026/01/ChristineLaPhotography-CA-UCSantaCruz-StudentLife-Day1-04092025-02192-1-scaled.jpg
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260212T114000
DTEND;TZID=America/Los_Angeles:20260212T133000
DTSTAMP:20260211T234252Z
CREATED:20260211T234225Z
LAST-MODIFIED:20260211T234252Z
UID:10009212-1770896400-1770903000@live-events-ucsc.pantheonsite.io
SUMMARY:BME Seminar: Population Genetics in an Era of Genomic Health
DESCRIPTION:Presenter: Dr. Eimear Kenny\, Founding Director of the Institute for Genomic Health and a Endowed Chair and Professor for Genomic Health at the Icahn School of Medicine at Mount Sinai \nDescription: The overarching goal of my work is to advance genomics in medicine and research through diversity and innovation. The work of my group seeks to enrich our understanding of human genomic diversity by focusing on populations underrepresented in genomics\, developing and disseminating computational genomic tools to enhance precision and accuracy in diverse populations\, unveiling genetic architectures of diseases that can track with demographic history\, and advancing diversity large-scale genomic databases. We also work to integrate new paradigms of genomic medicine into routine clinical practice\, ensuring genomic insights are appropriately applied in real-world healthcare settings and lead to improved patient care and health equity. I will discuss aspects of this work with emphasis on why we should promote inclusivity\, innovate methodologies\, and harness the potential of diverse populations in genomic health.  \nBio: Eimear Kenny\, PhD\, is the Founding Director of the Institute for Genomic Health\, building resources for integrating genomic information and AI in routine clinical care\, and supporting the sequencing and return of results to a diverse patients in the Mount Sinai Health System. She also the Founding Director of the Center for Translational Genomics and a Endowed Chair and Professor of Genomic Health\, at the Icahn School of Medicine at Mount Sinai\, working on computational and translational genomic research. She is Principal Investigator in many large NIH-funded international consortium focused on computational genomics and genomic medicine\, including eMERGE\, PRIMED\, CSER\, GSP\, TOPMed\, PAGE\, and HPRC. She is a strong advocate for the importance of diversity in genomic research\, is improving the accessibility of genetics to global populations\, and has led multiple genetics-based clinical trials. Her exceptional contributions to the field earned her the prestigious Early Career Award from the American Society of Human Genetics in 2022. In addition to her academic and research roles\, Dr. Kenny serves as a scientific advisor to various genomic medicine initiatives in government\, non-profit\, and industry sectors. \nHosted by: Professor Karen Miga\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/8123/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260129T114000
DTEND;TZID=America/Los_Angeles:20260129T131500
DTSTAMP:20260122T232352Z
CREATED:20260122T232352Z
LAST-MODIFIED:20260122T232352Z
UID:10009095-1769686800-1769692500@live-events-ucsc.pantheonsite.io
SUMMARY:BME 280B Seminar: Satellite repeats encode megabase-scale transcription factor hubs
DESCRIPTION:Presenter: Matt Franklin\, Postdoctoral Researcher\, Stanford University \nDescription: Eukaryotic genomes contain large stretches of repetitive DNA called satellite DNA\, often found near centromeres and ribosomal DNA regions. In humans\, alpha satellite has well-established roles in centromere biology\, however the functions of other human satellite DNAs remain largely unexplored. \nWe recently identified the Hippo pathway effector TEAD as a novel Human Satellite 3 (HSat3) binding TF. Because HSat3 is highly enriched near ribosomal DNA (rDNA) genes\, we examined whether the Hippo pathway regulates rDNA via HSat3. Our work demonstrates that HSat3 localizes the Hippo factors YAP and TEAD inside the nucleolus\, where YAP directly activates ribosomal RNA (rRNA) transcription. These findings present the first evidence that the Hippo pathway factor YAP directly regulates RNA Polymerase I activity. \nDisparate studies have identified examples of transcription factors that bind repetitive DNA elements through motif recognition. However\, a systematic search for such factors has not been conducted. Using Telomere-to-telomere genome assemblies\, we predicted and validated dozens of new satellite-binding TFs\, many of which are part of highly conserved signaling pathways. Beyond revealing a direct relationship between the Hippo pathway and ribosomal DNA regulation\, this work demonstrates that satellite DNA can encode a broad range of functional motifs\, hinting at new roles for these enormous genomic elements. \nBio: Following his undergraduate studies\, Matt conducted a 1-year research fellowship at EMBL Hamburg\, where he worked on X-ray scattering methods for structural biology. He then earned his PhD in chemical engineering at Stanford University\, where he investigated mechanotransduction and Hippo pathway signaling. Matt continued this research as a postdoc under Kun-Liang Guan at UC San Diego\, where he discovered that Hippo pathway effectors bind repetitive DNA elements. To expand on his newfound interest in repetitive DNA\, Matt returned to Stanford as a postdoctoral researcher under Nicolas Altemose\, where he is studying the functions of satellite repeats as hubs for transcription factor binding. \nHosted by: Professor Karen Miga\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-satellite-repeats-encode-megabase-scale-transcription-factor-hubs/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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GEO:36.9996638;-122.0618552
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Physical Sciences Building Physical Sciences Building Santa Cruz CA 95064;X-APPLE-RADIUS=500;X-TITLE=Physical Sciences Building:geo:-122.0618552,36.9996638
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260122T114000
DTEND;TZID=America/Los_Angeles:20260122T131500
DTSTAMP:20260115T232014Z
CREATED:20260115T232014Z
LAST-MODIFIED:20260115T232014Z
UID:10008410-1769082000-1769087700@live-events-ucsc.pantheonsite.io
SUMMARY:BME Seminar: Rotation Talks
DESCRIPTION:Presenter: Grad Students \nDescription: Rotation Talks \nBio: N/A \nHosted by: Professor Rebecca DuBois\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-seminar-rotation-talks/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
ATTACH;FMTTYPE=image/png:https://live-events-ucsc.pantheonsite.io/wp-content/uploads/2025/11/BE-logomark_localist.png
GEO:36.9996638;-122.0618552
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Physical Sciences Building Physical Sciences Building Santa Cruz CA 95064;X-APPLE-RADIUS=500;X-TITLE=Physical Sciences Building:geo:-122.0618552,36.9996638
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260112T170000
DTEND;TZID=America/Los_Angeles:20260112T183000
DTSTAMP:20251218T001742Z
CREATED:20251209T200526Z
LAST-MODIFIED:20251218T001742Z
UID:10005751-1768237200-1768242600@live-events-ucsc.pantheonsite.io
SUMMARY:Be Inspired: Explore Graduate Studies in STEM
DESCRIPTION:Not sure if graduate school is right for you? \nJoin us to learn what graduate school is really about and explore whether it’s the right path for you. We’ll cover topics such as qualifying exams\, funding options\, common misconceptions\, and more! \nClick the link below to register for the event: \nhttps://ucsc.zoom.us/webinar/register/WN_31OHhwc7QPqJ7nSyiuAUNg
URL:https://live-events-ucsc.pantheonsite.io/event/be-inspired-explore-graduate-studies-in-stem/
CATEGORIES:Seminars,Workshop
ATTACH;FMTTYPE=image/jpeg:https://live-events-ucsc.pantheonsite.io/wp-content/uploads/2025/12/Graduate-Student-Workshop-Flyer.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20260108T114000
DTEND;TZID=America/Los_Angeles:20260108T131500
DTSTAMP:20251216T231619Z
CREATED:20251216T231619Z
LAST-MODIFIED:20251216T231619Z
UID:10005856-1767872400-1767878100@live-events-ucsc.pantheonsite.io
SUMMARY:BME 280B Seminar: Nature’s Miniature Masterpieces - Nanobodies as Small but Mighty Antibodies for the next Pandemic
DESCRIPTION:Presenter: Katja Hanack\, Founder and CEO\, New/Era/Mabs \nDescription: Nanobodies combine remarkable simplicity with surprising power. Their small size allows them to reach targets that remain inaccessible to conventional antibodies\, while maintaining high specificity and stability. Their compact architecture allows them to access targets that conventional antibodies cannot reach\, yet they preserve the specificity and power that make antibody therapeutics so transformative. In this talk I will introduce the science behind selma\, a cell based discovery platform developed over more than a decade to rapidly identify high quality antibodies and nanobodies. I will explore why these tiny binders matter\, how they differ from classical antibodies\, and what their unique biology enables for diagnostics and therapeutics. \nThe presentation will conclude with my current project on immune infrastructure and how pre validated nanobody archives can shift the pandemic response from a reactive model to proactive preparedness for future outbreaks. \nBio: Katja Hanack\, PhD\, MBA\, is the Founder and CEO of new/era/mabs and a leading expert in antibody discovery for diagnostic and therapeutic applications\, with a particular focus on nanobody technologies. With more than 20 years of experience\, she has developed pioneering platforms that enable the efficient generation and selection of next-generation monoclonal antibodies and nanobodies. She holds a Biology degree from Humboldt University of Berlin and a PhD in Biotechnology from the University of Potsdam. As a former Professor of Biochemistry and Biology at the University of Potsdam\, she built and led a research group of 25 scientists\, secured over €16 million in external funding\, and authored more than 40 peer-reviewed publications. Since 2017\, Dr. Hanack has contributed to translational innovation as an industrial advisor for SPARK Stanford and SPARK Berlin\, supporting academic teams in bringing biomedical discoveries to patients. \nHosted by: Professor Rebecca Dubois\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-natures-miniature-masterpieces-nanobodies-as-small-but-mighty-antibodies-for-the-next-pandemic/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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GEO:36.9996638;-122.0618552
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251211T120000
DTEND;TZID=America/Los_Angeles:20251211T140000
DTSTAMP:20251209T224244Z
CREATED:20251209T224244Z
LAST-MODIFIED:20251209T224244Z
UID:10005759-1765454400-1765461600@live-events-ucsc.pantheonsite.io
SUMMARY:Chambers\, K. (BMEB) - Using Genomics and Artificial Intelligence to improve prognosis for osteosarcoma patients
DESCRIPTION:Transcriptomic profiling has been transformative in pediatric oncology. Pediatric cancers arise from disrupted developmental programs. Their impaired transcriptional states reflect cell lineage infidelity\, aberrant differentiation\, and immune-microenvironment interactions distinct from those of adult tumors(Gröbner et al.\, 2018; X. Ma et al.\, 2018). Within the osteosarcoma (OS) landscape\, despite being the most common bone tumor of childhood\, it remains one of the least genomically characterized pediatric cancers. Advancements in survival for localized disease\, outcomes for metastatic or recurrent OS have remained stagnant for decades. Transcriptomics characterization of OS has facilitated the exposure of the unique chromothripsis patterns associated with the disease (Sayles et al.\, 2019; Schott et al.\, 2023). Largely\, progress in OS genomics is still limited by the lack of harmonized\, cross-study datasets accessible to researchers. I detail my contributions to OS research\, beginning with the curation of the largest publicly available and harmonized RNA-sequencing osteosarcoma dataset (Chapter 2). A continuous part of my research involved the systematic democratization\, aggregation\, harmonization\, and open sharing of pediatric cancer transcriptomic datasets within the Treehouse Childhood Cancer Initiative (Beale et al.\, 2025). This dataset provided a foundation for the analyses and discoveries presented in this dissertation. I utilize the multi-cohort and transcriptomic multi-omic public OS dataset to discover and define biologically meaningful subtypes that may explain differences in progression and treatment response (Chapter 3). Finally\, I expand these advanced computational approaches into the realm of diagnostic pathology by evaluating strategies for integrating generative AI into rare cancer classification. I leverage both general and domain-specific diffusion models alongside GPT-4o–generated pathology prompts to guide histologic image synthesis (Chapter 4). In summary\, my work advances transcriptional subtyping in OS by leveraging transcriptomic data to identify molecular subtypes of OS that could inform treatment strategies. \nHost: Krizia Chambers\, Ph.D. Candidate\, Biomolecular Engineering & Bioinformatics  \nAdvisor: Olena Vaske \nZoom- https://ucsc.zoom.us/j/93569812001?pwd=RWBuZUdQq2Yo1K4kQ75WRmP0uKjYAH.1&jst=3 \nPasscode- 915392
URL:https://live-events-ucsc.pantheonsite.io/event/chambers-k-bmeb-using-genomics-and-artificial-intelligence-to-improve-prognosis-for-osteosarcoma-patients/
CATEGORIES:Ph.D. Presentations
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LOCATION:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251211T090000
DTEND;TZID=America/Los_Angeles:20251211T110000
DTSTAMP:20251209T161343Z
CREATED:20251202T162054Z
LAST-MODIFIED:20251209T161343Z
UID:10005717-1765443600-1765450800@live-events-ucsc.pantheonsite.io
SUMMARY:Tran\, L. (BMEB) -  Polysome Shadowing: A Long-Read Sequencing Approach to Study Translation
DESCRIPTION:Translation is a central and highly regulated step of gene expression\, yet there are few quantitative\, high-throughput tools to study translation. Existing methods such as sucrose gradients provide only bulk ribosome counts\, while Ribo-Seq offers positional information in the genome but destroys long-range structure and transcript expression information. Because of these limitations\, many fundamental questions about mRNA translation into protein remain difficult to assay. In this proposal\, I outline my plans to develop a novel technology\, deemed Polysome Shadowing\, that covalently marks ribosome-unprotected regions of RNA with hyperactive base editors. Because ribosomes protect ~21–30 nt regions of mRNAs\, ribosome “shadows” appear as tracts of unedited bases in long-read sequencing. In Aim 1\, I will identify ribosome shadows on single molecules by increasing editing efficiency through optimization of dual cytosine and adenosine base editors and statistical modeling. In Aim 2\, I will maximize the accuracy of information recovered from highly-edited RNAs by developing a multipass library preparation protocol to generate high-confidence reads. In Aim 3\, I will apply the tools I have already developed to examine previously difficult-to-assay paradigms of translational control in the form of viral frameshifting mechanisms. Together\, completion of these aims will build an information-rich sequencing technology capable of positioning ribosomes on intact mRNAs while preserving long-range information and establish feasibility to study nascent paradigms. \nHost: Liam Tran\, Ph.D. Student\, Biomolecular Engineering and Bioinformatics  \nAdvisor: Joshua Arribere 
URL:https://live-events-ucsc.pantheonsite.io/event/tran-l-bmeb-polysome-shadowing-a-long-read-sequencing-approach-to-study-translation/
LOCATION:Biomedical Sciences Building\, 575 McLaughlin Drive
CATEGORIES:Ph.D. Presentations
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GEO:46.1226939;-64.7891251
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Biomedical Sciences Building 575 McLaughlin Drive;X-APPLE-RADIUS=500;X-TITLE=575 McLaughlin Drive:geo:-64.7891251,46.1226939
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251204T114000
DTEND;TZID=America/Los_Angeles:20251204T131500
DTSTAMP:20251203T195447Z
CREATED:20251203T194937Z
LAST-MODIFIED:20251203T195447Z
UID:10005725-1764848400-1764854100@live-events-ucsc.pantheonsite.io
SUMMARY:BME 280B Seminar: Gali Bai & David Haussler
DESCRIPTION:Presenter 1: Gali Bai\, BME/PBSE Doctoral Candidate\, Brooks Lab\, UC Santa Cruz \nTitle 1: Dissecting the contribution of chromatin accessibility to RNA transcription and processing with long-read sequencing \nDescription: Although all cells in an organism share the same genomic sequence\, transcriptional programs vary dramatically across cell types. This diversity is governed by epigenetic regulation involving the coordinated activities of chromatin remodelers\, histone modifiers\, and histone chaperones that precisely modulate chromatin accessibility. While previous studies have shown that chromatin accessibility at DNase I–hypersensitive sites such as promoters and enhancers is closely associated with gene expression\, much less is known about how chromatin influences transcription and RNA processing. To study how chromatin regulates RNA processing\, we perturbed yeast chromatin accessibility by deleting two highly conserved chromatin remodelers ISW1 and CHD1. With Oxford Nanopore long-read sequencing\, we profiled nascent RNA\, full-length mRNA\, and chromatin fibers in wild-type and chd1 isw1 double-mutant yeast cells. Loss of ISW1 and CHD1 led to increased chromatin accessibility within intragenic regions\, accompanied by aberrant transcription initiation. Leveraging long-read data\, we associated distinct chromatin states with specific RNA processing events and isoform expression outcomes. Despite a similar level of chromatin perturbations across the genome\, genes with low baseline expression showed extensive transcriptional reprogramming\, whereas highly expressed genes remained largely unaffected. These discrepancies can be partially explained by differences in the enrichment of transcription initiation motifs. In intron-containing genes\, loss of ISW1 and CHD1 reduced splicing efficiency and increased intron retention\, likely due to disrupted RNAPII elongation in the double mutant. Together\, our findings highlight the crucial role of ATP-dependent chromatin remodelers in maintaining nucleosome organization and coordinating co-transcriptional RNA processing. \nPresenter 2: David Haussler\, Distinguished Professor\, UC Santa Cruz \nTitle 2: Brain Organoids \nBio: Haussler received his PhD in computer science from the University of Colorado at Boulder. He is a member of the National Academy of Sciences\, the National Academy of Engineering\, the American Academy of Arts and Sciences and a fellow of AAAS and AAAI. He has won a number of awards\, including the 2015 Dan David Prize\, the 2011 Weldon Memorial Prize from University of Oxford\, the 2009 ASHG Curt Stern Award in Human Genetics\, the 2008 Senior Scientist Accomplishment Award from the International Society for Computational Biology\, the 2005 Dickson Prize for Science from Carnegie Mellon University\, and the 2003 ACM/AAAI Allen Newell Award in Artificial Intelligence. \nHosted by: Professor Josh Stuart\, BME Department
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-gali-bai-david-haussler/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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GEO:36.9996638;-122.0618552
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Physical Sciences Building Physical Sciences Building Santa Cruz CA 95064;X-APPLE-RADIUS=500;X-TITLE=Physical Sciences Building:geo:-122.0618552,36.9996638
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251113T163000
DTEND;TZID=America/Los_Angeles:20251113T190000
DTSTAMP:20251017T180809Z
CREATED:20251017T180809Z
LAST-MODIFIED:20251017T180809Z
UID:10004908-1763051400-1763060400@live-events-ucsc.pantheonsite.io
SUMMARY:Leveraging UC Resources To Launch Your Biotech Company
DESCRIPTION:Are you a UCSC faculty member\, postdoc\, or graduate student with an entrepreneurial mindset? \nJoin us for an insightful panel discussion on how to turn your biotech research into a successful startup. Learn how to tap into the University of California’s robust innovation ecosystem—from research commercialization and funding opportunities to mentorship and startup incubation. \nHear firsthand from UC-affiliated founders\, investors\, and innovation experts who have successfully navigated the path from lab discovery to market launch. Stay afterward for a networking reception to connect with peers\, panelists\, and campus innovation partners. \nOpen to: UCSC faculty\, postdocs\, and graduate studentsLight refreshments provided. \nRegistration requested: https://luma.com/2gmhjlbo
URL:https://live-events-ucsc.pantheonsite.io/event/uc-resources-to-launch-your-biotech-company/
LOCATION:Hay Barn\, 94 Ranch View Road\, Santa Cruz\, CA\, 95064\, United States
CATEGORIES:Meetings & Conferences
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GEO:36.9817736;-122.0569624
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Hay Barn 94 Ranch View Road Santa Cruz CA 95064 United States;X-APPLE-RADIUS=500;X-TITLE=94 Ranch View Road:geo:-122.0569624,36.9817736
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251110T130000
DTEND;TZID=America/Los_Angeles:20251110T150000
DTSTAMP:20251028T155148Z
CREATED:20251028T155007Z
LAST-MODIFIED:20251028T155148Z
UID:10005010-1762779600-1762786800@live-events-ucsc.pantheonsite.io
SUMMARY:Nguyen\, R. (BMEB) - Development of Computational Methods for Reliable Genetic Identification of Forensic Samples
DESCRIPTION:Advances in sequencing technologies have enabled the recovery of genetic data from minimal\, contaminated\, and highly degraded samples\, overcoming long-standing barriers in forensic analysis. Nevertheless\, many evidentiary samples still yield poor-quality DNA that is unconducive to PCR amplification of short tandem repeats (STRs)\, microarray genotyping\, or deep sequencing necessary for accurate\, complete genotype calls. \nThis dissertation addresses these challenges through the development of computational methods for reliable identity analysis of forensic samples. First\, I present IBDGem\, a fast and robust computational procedure for detecting identity-by-descent (IBD) regions by comparing low-coverage sequence data from an unknown sample against SNP genotype calls from a known individual. Using data from the 1000 Genomes Project and a panel of 8 rootless hairs\, I demonstrate that IBDGem can detect relatedness segments at 1x coverage and achieve high-confidence identifications with as little as 0.01x coverage. \nThe next part of my thesis examines the characteristics of DNA derived from single\, rootless hairs and evaluates their potential as a source of forensic genetic information. Analyses of 80 rootless hair samples reveal DNA fragmentation patterns associated with endonuclease-mediated degradation and nucleosome positioning. This chapter also shows that even short segments of rootless hair shafts can yield adequate sequence data to generate statistical support for or against identity. \nFinally\, I present a comprehensive analysis of IBDGem’s performance across a range of data conditions and program settings. I find that IBDGem is robust to moderate input errors and can identify the major contributor in two-person mixtures. The method also reliably distinguishes self-comparisons from close-relative comparisons\, and remains effective even when limited to 94 target SNPs in the ForenSeq assay. Overall\, these findings establish IBDGem as a practical tool for analyzing trace DNA evidence when conventional methods are unsuccessful. \nEvent Host: Remy Nguyen\, Ph.D. Candidate\, Biomolecular Engineering & Bioinformatics  \nAdvisor: Ed Green \n  \nZoom- https://ucsc.zoom.us/j/91522009894?pwd=JWPSUcIi7IaZ4YOeLDQJohyRApos4T.1 \nPasscode- 854645
URL:https://live-events-ucsc.pantheonsite.io/event/nguyen-r-bmeb-development-of-computational-methods-for-reliable-genetic-identification-of-forensic-samples/
CATEGORIES:Ph.D. Presentations
ATTACH;FMTTYPE=image/jpeg:https://live-events-ucsc.pantheonsite.io/wp-content/uploads/2025/10/ph.d.-presentation-graphic-option2.jpg
LOCATION:
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251107T000000
DTEND;TZID=America/Los_Angeles:20251108T235959
DTSTAMP:20251023T232623Z
CREATED:20251013T212720Z
LAST-MODIFIED:20251023T232623Z
UID:10004811-1762473600-1762646399@live-events-ucsc.pantheonsite.io
SUMMARY:United Nations Reboot the Earth Hackathon
DESCRIPTION:The United Nations (UN) and the Baskin School of Engineering at the University of California\, Santa Cruz\, are collaborating to bring the “Reboot the Earth” hackathon to the West Coast for the first time. \nThis is a social event bringing together aspiring developers to create open source software solutions that address the climate crisis\, including wildfire response. It’s a chance to collaborate with peers\, use open data\, and apply your coding skills to real-world climate challenges! \n\n\n\nDate: November 7-8\, 2025\nLocation: UC Santa Cruz Silicon Valley Center.\nRegister here for the event. \n\nOrganized by the UN Office of Information and Communications Technology (OICT)\, the 2025  Reboot the Earth hackathons are focused on agriculture and artificial intelligence (AI). The California event will focus on the locally relevant challenges of wildfire detection\, response\, and impact. Participants can leverage open source\, AI\, and open data sets\, along with local expertise on the environment and emergency preparedness and response. The goal is to build solutions that can become a digital public good\, serving local community needs. \nUC Santa Cruz students interested in attending the event can take advantage of the Silicon Valley Connector shuttle\, which will be running on Saturday\, November 8\, in addition to the regular Friday schedule. \nTo learn more about the Reboot the Earth initiative\, visit: https://unite.un.org/en/reboot-earth.
URL:https://live-events-ucsc.pantheonsite.io/event/un-reboot-the-earth-hackathon/
LOCATION:Silicon Valley Campus\, 3175 Bowers Avenue\, Santa Clara\, CA\, 95054\, United States
CATEGORIES:Meetings & Conferences,Social Gathering
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251106T114000
DTEND;TZID=America/Los_Angeles:20251106T131500
DTSTAMP:20251106T012339Z
CREATED:20251106T012339Z
LAST-MODIFIED:20251106T012339Z
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SUMMARY:BME 280B Seminar: Anne Nakamoto\, Alan Zhang\, Shelbi Russell
DESCRIPTION:Presenter 1: Anne Nakamoto\, BME PhD Candidate\, Corbett-Detig Lab\, UC Santa Cruz \nTalk: Investigating deleterious mutation burden across populations and landscapes in the California Conservation Genomics Project \nDescription: Biodiversity is being lost at an accelerated rate due in part to anthropogenic forces\, posing a threat to the sustainability of Earth’s ecosystems as well as to human health. A major goal of conservation genomics is to use genomic data to understand population health\, which can inform management decisions for the preservation of biodiversity. The California Conservation Genomics Project (CCGP) is an extensive dataset containing species of conservation interest sampled across California\, allowing a landscape genomics approach to conservation. Among the many metrics that can be used to assess population health is genetic load\, which refers to the reduction in fitness imposed by deleterious mutations. In this work\, we construct a bioinformatic analysis framework to identify deleterious genomic variants in CCGP species based on evolutionary constraint. This allows us to investigate patterns in genetic burden across populations and the landscape of California. \nPresenter 2: Alan Zhang\, BME PhD Candidate\, Corbett-Detig Lab\, UC Santa Cruz \nTalk: Scalable Strain-Level Metagenomic Deconvolution and Assembly Using Pangenome Mutation-Annotated Networks \nDescription: Strain-level deconvolution of metagenomic samples is essential for pathogen surveillance\, mixed infection diagnosis\, and evolutionary genomics\, yet remains computationally challenging as genomic databases expand. Existing methods scale poorly with database size or rely exclusively on single nucleotide polymorphism (SNP) information. SNP-based approaches rely on mutation-annotated trees and thus require well-established reference genomes\, limiting their applicability to divergent species that lack alignable root references. We present panMAMA (panMAN Metagenomic Assignment and Metagenomic Assembly)\, a method that leverages the pangenome Mutation-Annotated Network (panMAN) data structure to enable accurate strain-level quantification across both closely related and divergent genomes. By employing k-min-mer-based pseudo-chaining with a seed-annotated tree index\, panMAMA achieves substantial computational speedup compared to existing k-mer-based tools while maintaining high accuracy. We demonstrate that panMAMA accurately deconvolves both closely related SARS-CoV-2 genomes and divergent HIV and respiratory syncytial virus (RSV) genomes\, outperforming existing tools including Freyja on simulated wastewater samples. Through a hybrid heuristic and maximum likelihood approach for read assignment and consensus calling\, panMAMA effectively recovers variant genomes from low-heterogeneity samples of divergent species. These results establish panMAMA as a scalable and accurate platform that extends strain-level metagenomic analysis to previously intractable highly divergent species. \nPresenter 3: Shelbi Russell\, PhD\, UC Santa Cruz\, Ph.D.\, Organismic & Evol Bio\, Harvard\, PostDoc MCDB\, UC Santa Cruz \nDescription: Many animals harbor bacterial symbionts that manipulate host reproduction to enhance bacterial survival and transmission. Obligate intracellular symbionts\, such as Wolbachia pipientis\, are particularly adept at host manipulation\, influencing reproductive biology and even blocking viral replication. These bacterially induced traits have been harnessed in field studies to control mosquito populations and limit the spread of human pathogens like Dengue and Zika viruses. Despite these promising applications\, the molecular mechanisms underlying Wolbachia’s interactions with host cells remain poorly understood. Furthermore\, even less is known about the implications of these symbionts spreading to non-target hosts in the ecosystem. Previous work from my lab tackled these questions in vivo: we discovered that the wMel strain of Wolbachia can enhance host fertility and we discovered that even extremely low rates of horizontal symbiont transmission among hosts can influence bacterial genome evolution. However\, in vivo systems offer limited resolution to identify the precise cellular mechanisms of fertility enhancement and the real-time genomic impacts of horizontal transmission. Here\, we use an in vitro Drosophila system to 1) identify the cell type-specific impacts of Wolbachia infection on host-microbe interactions and 2) characterize how strains interact within host tissues during mixed infections. This simplified\, easy to sample system enabled us to concentrate the effects of host cell type on Wolbachia gene expression and to control de novo strain infections and mixtures. Through these experiments\, we discovered that different host cell types induce differential Wolbachia gene expression that feeds back to alter host gene expression and epigenetic silencing. These findings have motivated on-going single cell RNAseq work to resolve the process at the single cell level\, during de novo infections. Results from the experimental mixed infections revealed highly reproducible strain and cell type-specific dynamics. We will leverage these discoveries to understand strain-specific tissue tropisms and how multiple strains can co-exist as superinfections in nature\, which will inform future biocontrol strategies. \nBio: Shelbi is an Assistant Professor in the Department of Biomolecular Engineering at UCSC. She started her lab in 2022\, after completing her PhD at Harvard University in 2016 and performing her postdoctoral work at UCSC. Her passion for studying symbiotic systems began as an undergraduate researcher at the University of Kansas describing new tapeworm species. She transitioned to studying the evolutionary genomics of bacterial-animal mutualisms in her PhD and was awarded the UC Chancellor’s Postdoctoral Fellowship and the NIH Career Development Award (K99) to test genomic hypotheses in the Wolbachia-Drosophila model system during her postdoc. As faculty\, she is working to learn how hosts and microbes function and evolve so we can engineer associations for biological control. She has authored 24 papers and obtained $2.75 million in funding. Her interdisciplinary training makes her uniquely qualified to lead these investigations and has enabled novel breakthroughs in our understanding of symbiont evolution and microbe-induced host phenotypes. \nHosted by: Professor Josh Stuart\, BME Department \nRoom: PSB-240
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-anne-nakamoto-alan-zhang-shelbi-russell/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251030T114000
DTEND;TZID=America/Los_Angeles:20251030T131500
DTSTAMP:20251028T222750Z
CREATED:20251028T222750Z
LAST-MODIFIED:20251028T222750Z
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SUMMARY:BME 280B Seminar: Preconfigured neuronal firing sequences in human brain organoids
DESCRIPTION:Presenter: Tjitse (TJ) van der Molen\, Ph.D. (Postdoc\, Sharf Lab\, UC Santa Cruz and PhD Kosik Lab\, UC Santa Barbara) \nDescription: Neuronal firing sequences are thought to be the building blocks of information and broadcasting within the brain. Yet\, it remains unclear when these sequences emerge during neurodevelopment. Here we demonstrate that structured firing sequences appear in spontaneous activity of human and murine brain organoids\, both unguided and forebrain identity directed\, as well as ex vivo neonatal murine cortical slices. We observed temporally rigid and flexible firing patterns in human and murine brain organoids and early postnatal murine somatosensory cortex\, but not in dissociated primary cortical cultures. These results suggest that temporal sequences do not arise in an experience-dependent manner\, but are rather constrained by a preconfigured architecture established during neurodevelopment. By demonstrating the developmental recapitulation of neural firing patterns\, these findings highlight the potential of brain organoids as a model for neuronal circuit assembly. \nBio: Tjitse van der Molen studies spontaneous and evoked neural circuit activity in human and mouse stem cell derived brain organoids using dense multi electrode arrays. His main goal is to gain a better understanding of how healthy neural circuits process information and how possible malfunctions in neural circuit activity may result in disease\, in order to develop appropriate treatments. Tjitse recently completed his PhD in the Kosik lab at UC Santa Barbara and is now continuing his research as a postdoc in the Sharf lab at UC Santa Cruz. \nIn this talk\, Tjitse will present his latest manuscript that is currently in press with Nature Neuroscience\, focused on spontaneously occurring repeated sequential firing patterns that are present in the intrinsic activity of both brain organoids and neonatal mouse brain slices but not in 2D primary cultures. Similar sequential firing patterns have recently been shown to be important for information encoding and learning in the human cortex. The presence of these sequential firing patterns in the spontaneous activity of brain organoids that have never received external stimuli supports the notion that they develop in an experience-independent manner. \nHosted by: Professor Josh Stuart\, BME Department \nZoom Link: https://ucsc.zoom.us/j/99970819390?pwd=8sl5pd5TTBA5f6nqyCzo5mFpaqcEJG.1 \nFull Schedule: https://docs.google.com/document/d/1xD09vITwd_Pj9Ge6hHEuBFa5zBUYu2O-bjpSibt7VHE/edit?tab=t.0 \nRoom: PSB-240
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-preconfigured-neuronal-firing-sequences-in-human-brain-organoids/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251024T140000
DTEND;TZID=America/Los_Angeles:20251024T150000
DTSTAMP:20251009T181205Z
CREATED:20251009T181205Z
LAST-MODIFIED:20251009T181205Z
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SUMMARY:Science & Justice Training Program Informational Meeting
DESCRIPTION:Join the Science & Justice Research Center on Friday\, October 24th at 2PM on Zoom for an Informational Meeting on our internationally recognized interdisciplinary Graduate Training and Certificate Program. \nRegister at: https://ucsc.zoom.us/meeting/register/u6h-cJvDQBiscaNIJpzVUw. \nOur Science & Justice Training Program (SJTP) is a globally unique initiative that trains doctoral students to work across the disciplinary boundaries of the natural and social sciences\, engineering\, humanities and the arts. Through the SJTP we at UC Santa Cruz currently teach new generations of PhD students the skills of interdisciplinary collaboration\, ethical deliberation\, and public communication. Students in the program design collaborative research projects oriented around questions of science and justice. These research projects not only contribute to positive outcomes in the wider world\, they also become the templates for new forms of problem-based and collaborative inquiry within and beyond the university. \nAs SJTP students graduate they take the skills and experience they gained in the training program into the next stage of their career in universities\, industry\, non-profits\, and government. \nOpportunities include graduate Certificate Program\, experience organizing and hosting colloquia series about the research projects\, mentorship\, potential for additional research funding and training in conducting interdisciplinary research at the intersections of science and society. \nWINTER 2026 / WINTER 2027 COURSE SERIES:\nScience & Justice: Experiments in Collaboration\, taught by Associate Professor of Critical Race Science and Technology Studies Kriti Sharma is scheduled for Tuesday’s 1:00-4:00 pm. Science and Justice Research Seminar will be offered in Winter 2027. Enrollment in the courses is required for participating in the Training Program. Attending the informational meeting is strongly encouraged\, but not required. \nStudents from all disciplines are encouraged to attend. Prior graduate fellows have come from every campus Division and have represented 24 departments. \nPast collaborative research projects have included: \n\nPhysicists working with small scale farmers to develop solar greenhouses scaled to local farming needs.\nColloquia about the social and political consequences of scientific uncertainties surrounding topics such as climate change research\, food studies\, genomics and identity.\nExamining how art can empower justice movements.\nWorking with local publics to improve African fishery science.\n\nFor more information on the Science & Justice Training Program\, visit: https://scijust.ucsc.edu/about-sjrc/sjtp/.
URL:https://live-events-ucsc.pantheonsite.io/event/science-justice-training-program-informational-meeting/
CATEGORIES:Lectures & Presentations,Meetings & Conferences
LOCATION:Register at: https://ucsc.zoom.us/meeting/register/u6h-cJvDQBiscaNIJpzVUw
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251023T114000
DTEND;TZID=America/Los_Angeles:20251023T131500
DTSTAMP:20251022T183840Z
CREATED:20251020T204418Z
LAST-MODIFIED:20251022T183840Z
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SUMMARY:BME 280B Seminar: Computational Models of Biological Systems
DESCRIPTION:Presenter: Chen-Hsiang Yeang\, Associate Research Fellow\, Institute of Statistical Science of Academia Sinica \nDescription: Computational models are roughly categorized into two types: describing the patterns of the phenomenon or data (description-driven models) and explaining the phenomenon or data with simpler\, comprehensible rules (explanation-driven models). When building a model\, the choice of the mixture ingredients of these two classes depends on the nature of the problem\, availability of the knowledge and data of the underlying system. In this talk\, I will give an overview of five models with varying combinations of descriptive and explanatory elements on different biological problems. First\, I will introduce a joint model to capture irreversible and reversible drug resistance mechanisms of cancers and a dynamic treatment strategy to tackle drug resistance. Second\, I will introduce a backward deconvolution algorithm based on probabilistic graphical models to unravel the cell type heterogeneity of the RNASeq data. Third\, I will introduce a deep neural network model to integrate direct and indirect associations of genotypes and images with phenotypes. Fourth\, I will introduce an experimental and computational framework to predict protein stability and discover motifs at C-terminals. Fifth\, I will introduce three algorithms to demarcate independent holes of specified dimensions in large networks. These works illustrate how “model selection” should be tailored for specific biological problems. \nBio: Chen-Hsiang Yeang is currently an associate research fellow at the Institute of Statistical Science of Academia Sinica. His research interests focus on several areas in computational biology and data science: 1) cancer genomics\, 2) cancer treatment\, 3) molecular evolution\, 4) network topology\, and 5) machine learning. \nHosted by: Professor Josh Stuart\, BME Department \nRoom: PSB-240
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-computational-models-of-biological-systems/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251021T120000
DTEND;TZID=America/Los_Angeles:20251021T130000
DTSTAMP:20251014T141340Z
CREATED:20251013T151834Z
LAST-MODIFIED:20251014T141340Z
UID:10004809-1761048000-1761051600@live-events-ucsc.pantheonsite.io
SUMMARY:CITRIS Aviation Prize Information Session
DESCRIPTION:Join us for this virtual info session on the 2025–26 CITRIS Aviation Prize\, an exciting multi-campus student competition inviting teams to design innovative solutions for the future of air mobility across the University of California. \nThe session will cover this year’s competition guidelines\, key dates and requirements\, and available resources. Attendees will also have the opportunity for Q&A with members of the CITRIS Aviation Leadership Committee\, composed of aviation research faculty from UC Berkeley\, UC Davis\, UC Merced\, and UC Santa Cruz. \nRegister here to attend. \nFor any questions\, contact aviationprize@citris-uc.org. \n  \nDate: Tuesday\, October 21 \nTime: 12:00 pm – 1:00 pm \nLocation: Zoom (register to attend).
URL:https://live-events-ucsc.pantheonsite.io/event/citris-aviation-prize-info/
CATEGORIES:Meetings & Conferences
ATTACH;FMTTYPE=image/jpeg:https://live-events-ucsc.pantheonsite.io/wp-content/uploads/2025/10/2025-Aviation-Prize-graphic.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20251015T110000
DTEND;TZID=America/Los_Angeles:20251015T110000
DTSTAMP:20250924T212046Z
CREATED:20250924T212046Z
LAST-MODIFIED:20250924T212046Z
UID:10000051-1760526000-1760526000@live-events-ucsc.pantheonsite.io
SUMMARY:2025 Fall STEM Career & Internship Fair
DESCRIPTION:Here is a chance to meet tech recruiters in person! \nIf you are interested in pursuing a career in science\, technology\, engineering\, mathematics or research\, then take advantage of this opportunity to meet recruiters from companies looking to fill various positions (both technical and non-technical). Learn more about internships and full-time career opportunities. Undergraduate students\, graduate students\, and recent alumni are all welcome to attend! \nPLEASE NOTE: You are encouraged to check in at the student registration table in order to participate in the career fair. Bring your student ID. \nWant more support? \n\nVisit a peer coach during drop-in hours\nSchedule a career coaching appointment with a Career Engagement Specialist\nFor PhD students looking to pursue careers in industry\, explore Beyond the Professoriate\n	(Scroll over "Login to Platform" at the top navigation bar and click "Through your institution")\nGet career tips on demand from our Career Success YouTube video library\nStay in the loop by following Career Success on Instagram\n\nYou will receive registration and additional information in your email from Career Success via Handshake. Please make sure to check your junk/spam folder if you are not receiving any communication.\n  \nYou Belong Here: The programs and services described here are open to all\, consistent with state and federal law\, as well as the University of California’s nondiscrimination policies. Every initiative—whether a student service\, faculty program\, or community event—is designed to be accessible\, inclusive\, and respectful of all identities. \nTo learn more\, please visit UC Nondiscrimination Statement or Nondiscrimination Policy for UC Publications. \nQuestions? Send to csuccess@ucsc.edu or visit Career Success at Hahn 125 East Entrance\nNeed accessibility support? Let us know at slugtalent@ucsc.edu at least two weeks prior to the fair date.
URL:https://live-events-ucsc.pantheonsite.io/event/2025-fall-stem-career-internship-fair/
LOCATION:Stevenson Event Center\, Stevenson Service Road\, Santa Cruz\, CA\, 95064
CATEGORIES:Meetings & Conferences
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END:VCALENDAR