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SUMMARY:BME 280B Seminar: Speaker Julian Lucas & Speaker Theo Kell
DESCRIPTION:Title of Talk 1: Enabling Population-Scale Analysis of Human Centromere Diversity \nPresenter 1: Julian Lucas\, Graduate Student in Miga Lab\, University of California\, Santa Cruz \nDescription: Centromeres are essential for chromosome segregation\, yet their repetitive DNA has long been a blind spot in human genomics. Until recently\, they were largely missing from reference genomes\, and they are still omitted from many genomic analyses due to their rapid sequence divergence. Reference-quality assemblies from the Human Pangenome Reference Consortium (HPRC) now make it possible to compare centromeres across hundreds of human haplotypes. I will describe how we built these assemblies and developed methods to align their repetitive satellite arrays. Together\, these form a centromere pangenome that represents variation and supports analysis such as read mapping\, making centromeres accessible to genomics. Our analysis reveals large structural differences in and around centromeres\, as well as unexpected patterns in single-base changes that offer clues to how centromeric DNA evolves. \nBio: Julian is a graduate student in Karen Miga’s laboratory at the University of California\, Santa Cruz. His research uses pangenomes to characterize variation in human centromeres\, with the goal of bringing these historically difficult-to-analyze regions into mainstream human genetics. Recently\, he helped lead the assembly effort for Release 2 of the Human Pangenome Reference Consortium (HPRC)\, which produced reference-quality genome assemblies that better capture human genetic diversity. Before graduate school\, Julian worked at biotechnology startups\, most recently in non-invasive cancer detection. \nHosted by: Professor Karen Miga\, BME Department \nTitle of Talk 2: Genomics Institute Computing Resources \nPresenter 2: Theo Kell\, Senior Systems Architect\, UC Santa Cruz Genomics Institute \nDescription: The backbone of the bioinformatics research at the Genomics Institute is its computing infrastructure. Members of the Genomics Institute have access to a wide array of resources\, including petabytes of storage capacity\, and a supercomputer cluster with over 7\,000 cores. There are also systems for hosting public websites\, sharing datasets with the world\, and collaborating on coding projects. The Genomics Institute IT team works with all stakeholders to make sure that the computing resources are accessible\, up-to-date\, and optimized for cutting-edge\, massively parallel bioinformatics research. \nThis presentation will give an overview of the computing assets that are available\, explain how they are used\, and elaborate on best practices. It is intended to be approachable for students who do not yet have experience with programming or using the command line\, while also providing a jumping-off point for students who are ready to dive in and begin running code. \nBio: Theo Kell is a Senior Systems Architect at the UC Santa Cruz Genomics Institute. After graduating from the Baskin School of Engineering’s Technology and Information Management program\, he worked as an IT System Administrator at Moss Landing Marine Laboratories and Cabrillo College before returning to UCSC to join the Genomics Institute IT team. He has a broad background in Linux/Unix systems\, virtualization\, cybersecurity\, networking\, and customer support.
URL:https://live-events-ucsc.pantheonsite.io/event/bme-280b-seminar-speaker-julian-lucas-speaker-theo-kell-genomics-institute-computing-resources/
LOCATION:Physical Sciences Building\, Physical Sciences Building\, Santa Cruz\, CA\, 95064
CATEGORIES:Lectures & Presentations,Seminars
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DTSTART;TZID=America/Los_Angeles:20261022T140000
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SUMMARY:Wiki-a-thon  to support BIPOC Scientists and Engineers
DESCRIPTION:Wikipedia overwhelmingly recognizes the achievements of white people. Join us as we add wikipedia pages for BIPOC leaders in science and technology\, highlighting their often overlooked accomplishments and ensuring that the next generation can see role models who look like them. \n\n\n\nNo experience is necessary – just bring a laptop! \n\n\n\n\nWe will provide a list of scientists who don’t yet have pages\, or you can come up with your own! The event will begin with a short training on how to edit Wikipedia\, followed by time to write your own article on a scientist\, engineer\, or technologist of your choice. \nRSVP here \nPlease RSVP above for a Zoom link if you will be attending virtually\, or to let us know that you are coming in person. Snacks will be provided!
URL:https://live-events-ucsc.pantheonsite.io/event/wiki-a-thon-to-support-bipoc-scientists-and-engineers/
LOCATION:Jack Baskin Engineering\, Baskin Engineering 1156 High Street\, Santa Cruz\, CA\, 95064
CATEGORIES:Social Gathering,Training,Undergraduate,Volunteer
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