The 26th Annual UC Systemwide Bioengineering Symposium (BIC 2026) is taking place at UC Santa Cruz on August 22-23, 2026. The event will bring together faculty, researchers, students, industry representatives, […]
The 26th Annual UC Systemwide Bioengineering Symposium (BIC 2026) is taking place at UC Santa Cruz on August 22-23, 2026. The event will bring together faculty, researchers, students, industry representatives, non-profit organizations, and other stakeholders to explore bioengineering & AI in the heart of the redwood forest. BIC 2026 will foster new collaborations and showcase […]
The COVID-19 pandemic generated genomic data at unprecedented scale, with tens of millions of SARS-CoV-2 genomes deposited in public repositories and thousands of new sequences added each day. This dissertation develops methods for analyzing genomic datasets at this scale, unified by the idea that encoding genomes according to their evolutionary relationships can make otherwise intractable […]
Many somatic variant-calling pipelines begin by aligning tumor and matched-normal sequencing reads to a single linear reference genome, such as GRCh38. Because every individual differs substantially from this reference, this approach can introduce reference bias, causing reads to map incorrectly or not at all and potentially leading to missed somatic variants or germline variants being […]