Lectures & Presentations

Centromeres ensure proper chromosome segregation during cell division, yet the organization and regulation of centromeric chromatin within satellite DNA arrays remain incompletely understood. Here, we leverage the complete diploid human genome benchmark (T2T-HG002) to provide a detailed study of centromeric sequence and chromatin architecture on individual haplotypes. Using adaptive-sampling-enriched, ultra-long-read DiMeLo-seq, we achieve single-molecule chromatin […]

As quantum computing transitions from theory to practice, understanding which algorithms suit near-term devices becomes critical. Current quantum computers are severely constrained by limited qubit counts, short coherence times, and high error rates that quickly degrade computation into noise. This thesis addresses two interconnected questions: what non-trivial computational tasks can near-term devices execute and how […]

Many genetics pipelines start by aligning sequencing reads to a reference genome. Aligners attempt to find the position in the reference sequence which best matches the read sequence, but this breaks down when the reads come from a sample with variation relative to the reference. A proposed alternative, pangenome graphs, is supposed to fix such […]

Self-reflection holds significant potential for learning, behavior change, and emotional processing, yet designing technologies that effectively support it remains challenging, particularly when reflection involves difficult experiences such as failure. Most current technologies avoid negative experiences altogether, leaving users without support at precisely the moments when reflection could be most valuable. This dissertation investigates how technology […]

The growing complexity of high-performance computing (HPC) systems poses a fundamental challenge for domain scientists, whose primary objective is to obtain scientifically valid results rather than to optimize resource utilization. Modern leadership-class facilities combine heterogeneous CPUs, GPUs, and specialized accelerators across systems that simultaneously support traditional scientific simulations and AI-driven workloads. This creates a vast, […]

Modern software increasingly relies on distributed systems to provide accessible, scalable, and reliable services. Choreographic programming brings a global perspective to distributed system development: programmers write a single program that describes the behavior of a whole system, and a compiler projects that global description into local programs run by each node. By making distributed control […]